A Study on polypharmacy and potential drug – drug interactions in tertiary care hospital is beneficial for reducing the medication errors, adverse drug reactions and for improving the patients’ therapeutic outcomes. Drug interaction refers to modification of response to one drug by another drug when they are administered together; which can be severe, moderate or minor and also which is an important cause of adverse drug reactions (ADRs). A prospective interventional study was carried out for a period of six months from November 2017 to April 2018, in the inpatient departments of pediatric, oncology, surgery, general medicine, obstetrics and gynecology of two different tertiary care hospitals in Mysore District, with aim of evaluating potential drug interactions. The data are collected on patient’s demographic details, complaints, past medical history, current medications along with their ADRs. Potential drug –drug interactions (pDDIs) were identified using Medscape drug interaction checker. The data were analyzed using SPSS software. The Mean ± Standard deviation for age distribution found in our study was 35.69 ± 27.43. The total potential drug-drug interactions found in our study is 55.7%. Out of this Moderate pDDIs were most prevalent followed by Minor (14.81%) and Severe (9.42%).This study concluded that potential drug interactions are one of the major concerns that every patient under therapy with multiple drugs prescription suffer from which is a major challenge for ensuring drug safety along with effective treatment by systematic drug monitoring for potential interactions.
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